Serednye Vodiane was known as Mitl Apsa in Yiddish. Jews most likely settled in Serednye Vodiane in the late 18th century. By 1941, the Jewish population had increased to 412. However, at this time Jewish families without Hungarian citizenship were expelled to the Nazi-occupied Ukrainian territory of Kamenets-Podolski, where they were murdered. The remaining Jews in Serednye Vodiane were deported to Auschwitz in late May, 1944.